University of Sussex
Browse

File(s) not publicly available

Dynamic assembly of surface structure in living cells

journal contribution
posted on 2023-06-07, 22:39 authored by Julia Gorelik, Andrew I Shevchuk, Gregory I Frolenkov, Ivan A Diakonov, Max J Lab, Corne Kros, Guy Richardson, Igor Vodyanoy, Christopher R W Edwards, David Klenerman, Yuri E Korchev
Although the dynamics of cell membranes and associated structures is vital for cell function, little is known due to lack of suitable methods. We found, using scanning ion conductance microscopy, that microvilli, membrane projections supported by internal actin bundles, undergo a life cycle: fast height-dependent growth, relatively short steady state, and slow height-independent retraction. The microvilli can aggregate into relatively stable structures where the steady state is extended. We suggest that the intrinsic dynamics of microvilli, combined with their ability to make stable structures, allows them to act as elementary ¿building blocks¿ for the assembly of specialized structures on the cell surface.

History

Publication status

  • Published

Journal

Proceedings of the National Academy of Sciences

ISSN

0027-8424

Publisher

National Academy of Sciences

Issue

10

Volume

100

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC