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Exploring the molecular nature of alternative oxidase regulation and catalysis.

journal contribution
posted on 2023-06-08, 05:18 authored by Charles Affourtit, Mary Albury, Paul G Crichton, Anthony Moore
Plant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water. In this paper we review theoretical and experimental studies that have contributed to our current structural and mechanistic understanding of the oxidase and to the clarification of the molecular nature of post-translational regulatory phenomena. Furthermore, we suggest a catalytic cycle for AOX that involves at least one transient protein-derived radical. The model is based on the reviewed information and on recent insights into the mechanisms of cytochrome c oxidase and the hydroxylase component of methane monooxygenase.

History

Publication status

  • Published

Journal

FEBS Letters

ISSN

0014-5793

Issue

3

Volume

510

Page range

121-126

Department affiliated with

  • Biochemistry Publications

Notes

Co-authors all post docs in my lab where the work was carried out.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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