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Exploring the molecular nature of alternative oxidase regulation and catalysis.
journal contribution
posted on 2023-06-08, 05:18 authored by Charles Affourtit, Mary Albury, Paul G Crichton, Anthony MoorePlant mitochondria contain a non-protonmotive alternative oxidase (AOX) that couples the oxidation of ubiquinol to the complete reduction of oxygen to water. In this paper we review theoretical and experimental studies that have contributed to our current structural and mechanistic understanding of the oxidase and to the clarification of the molecular nature of post-translational regulatory phenomena. Furthermore, we suggest a catalytic cycle for AOX that involves at least one transient protein-derived radical. The model is based on the reviewed information and on recent insights into the mechanisms of cytochrome c oxidase and the hydroxylase component of methane monooxygenase.
History
Publication status
- Published
Journal
FEBS LettersISSN
0014-5793External DOI
Issue
3Volume
510Page range
121-126Department affiliated with
- Biochemistry Publications
Notes
Co-authors all post docs in my lab where the work was carried out.Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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