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Nitric oxide in septic shock

journal contribution
posted on 2023-06-08, 06:06 authored by Michael Titheradge
Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock.

History

Publication status

  • Published

Journal

BBA - Bioenergetics

ISSN

0005-2728

Publisher

Elsevier

Issue

2-3

Volume

1411

Page range

437-455

ISBN

0006-3002

Department affiliated with

  • Biochemistry Publications

Notes

Invited review in special issue on Nitric Oxide Biochemistry

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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