9776.full.pdf (623.56 kB)
Enhancement of synchronization in a hybrid neural circuit by spike timing dependent plasticity
journal contribution
posted on 2023-06-08, 08:35 authored by Thomas NowotnyThomas Nowotny, Valentin P Zhigulin, Allan I Selverston, Henry D I Abarbanel, Mikhail I RabinovichSynchronization of neural activity is fundamental for many functions of the brain. We demonstrate that spike-timing dependent plasticity (STDP) enhances synchronization (entrainment) in a hybrid circuit composed of a spike generator, a dynamic clamp emulating an excitatory plastic synapse, and a chemically isolated neuron from the Aplysia abdominal ganglion. Fixed-phase entrainment of the Aplysia neuron to the spike generator is possible for a much wider range of frequency ratios and is more precise and more robust with the plastic synapse than with a nonplastic synapse of comparable strength. Further analysis in a computational model of HodgkinHuxley-type neurons reveals the mechanism behind this significant enhancement in synchronization. The experimentally observed STDP plasticity curve appears to be designed to adjust synaptic strength to a value suitable for stable entrainment of the postsynaptic neuron. One functional role of STDP might therefore be to facilitate synchronization or entrainment of nonidentical neurons.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of NeuroscienceISSN
0270-6474Publisher
Society for NeurosciencePublisher URL
Issue
30Volume
23Page range
9776-9785Pages
10.0Department affiliated with
- Informatics Publications
Notes
Originality: Demonstrates the role of spike-timing dependent plasticity for synchronizing neural activity in a novel hybrid circuit experiment. The results are relevant for many questions, in particular regarding brain rhythms. Rigour: The work comprises hybrid systems experiments with a custom developed soft-real-time system and theoretical modeling work. Significance: The work has introduced a further application of dynamic clamp to the field by, for the first time, implementing plasticity of artificial synapses. The developed dynamic clamp software has since become one of the most popular dynamic clamp packages on the web according to a recent review (Prinz AA et al. (2004) Trends Neurosci 27(4):218-224). Impact: This article has received 10 citations according to Google Scholar.Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06First Open Access (FOA) Date
2016-03-22First Compliant Deposit (FCD) Date
2016-11-10Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC