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Structural analyses of fibrinogen amyloid fibrils

journal contribution
posted on 2023-06-08, 08:38 authored by Louise SerpellLouise Serpell, Merrill Benson, Juris J Liepnieks, Paul E Fraser
Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aa-chain. To investigate the structure of fibrinogen amyloid, fibrils were extracted from the tissues of a patient and studied by X-ray fiber diffraction and electron microscopy. We have carried out a full structural characterization of amyloid fibrils taken from disease tissue. These studies revealed that ex vivo fibrinogen amyloid fibrils have a cross-ß structure similar to other chemical types of amyloid fibrils.

History

Publication status

  • Published

Journal

Amyloid

ISSN

1350-6129

Issue

3

Volume

14

Page range

199-203

Pages

5.0

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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