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Structural analyses of fibrinogen amyloid fibrils
journal contribution
posted on 2023-06-08, 08:38 authored by Louise SerpellLouise Serpell, Merrill Benson, Juris J Liepnieks, Paul E FraserHereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aa-chain. To investigate the structure of fibrinogen amyloid, fibrils were extracted from the tissues of a patient and studied by X-ray fiber diffraction and electron microscopy. We have carried out a full structural characterization of amyloid fibrils taken from disease tissue. These studies revealed that ex vivo fibrinogen amyloid fibrils have a cross-ß structure similar to other chemical types of amyloid fibrils.
History
Publication status
- Published
Journal
AmyloidISSN
1350-6129External DOI
Issue
3Volume
14Page range
199-203Pages
5.0Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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