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The probability of neurotransmitter release: variability and feedback control at single synapses

journal contribution
posted on 2023-06-08, 09:01 authored by Tiago Branco, Kevin StarasKevin Staras
Information transfer at chemical synapses occurs when vesicles fuse with the plasma membrane and release neurotransmitter. This process is stochastic and its likelihood of occurrence is a crucial factor in the regulation of signal propagation in neuronal networks. The reliability of neurotransmitter release can be highly variable: experimental data from electrophysiological, molecular and imaging studies have demonstrated that synaptic terminals can individually set their neurotransmitter release probability dynamically through local feedback regulation. This local tuning of transmission has important implications for current models of single-neuron computation.

History

Publication status

  • Published

Journal

Nature Reviews Neuroscience

ISSN

1471-003X

Volume

10

Page range

373-383

Pages

11.0

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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