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The probability of neurotransmitter release: variability and feedback control at single synapses
Information transfer at chemical synapses occurs when vesicles fuse with the plasma membrane and release neurotransmitter. This process is stochastic and its likelihood of occurrence is a crucial factor in the regulation of signal propagation in neuronal networks. The reliability of neurotransmitter release can be highly variable: experimental data from electrophysiological, molecular and imaging studies have demonstrated that synaptic terminals can individually set their neurotransmitter release probability dynamically through local feedback regulation. This local tuning of transmission has important implications for current models of single-neuron computation.
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Publication status
- Published
Journal
Nature Reviews NeuroscienceISSN
1471-003XExternal DOI
Volume
10Page range
373-383Pages
11.0Department affiliated with
- Neuroscience Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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