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Nitric oxide, sepsis and liver metabolism
journal contribution
posted on 2023-06-08, 09:29 authored by E D Ceppi, F S Smith, Michael TitheradgeTreatment of rats with bacterial endotoxin (LPS) significantly lowers hepatic gluconeogenesis and induces nitric oxide (NO) synthase over 18 hours. The induction of NO synthase correlates with alterations in plasma nitrate plus nitrite, and also with an inhibition of glucose synthesis in subsequently isolated hepatocytes. Artifical NO donors similarly decrease glucose synthesis. Cultured hepatocytes treated with a mixture of LPS, interferon-¿, tumour necrosis factor-a and IL-1ß show a similar inhibition of glucose output and induction of NO synthase, although NO synthase inhibitors can only partially reverse the inhibition of glucose output. Inclusion of glucagon during the induction period diminishes the ability of the cytokines to induce NO synthase and attenuates the inhibitory effect on glucose output. The inhibitory effect of glucagon on the expression of NO synthase can be mimicked by dibutyryl cyclic AMP and forskolin.
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Publication status
- Published
Journal
Biochemical Society TransactionsISSN
03005127External DOI
Issue
3Volume
25Page range
929-934Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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