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Anti-heat shock protein 27 titers and oxidative stress levels are elevated in patients with valvular heart disease
journal contribution
posted on 2023-06-08, 13:46 authored by Amir Ali Rahsepar, Asadollah Mirzaee, Fatemeh Moodi, Mohsen Moohebati, Shima Tavallaie, Ali Eshraghi, Maryam-Sadat Alavi, Laya Zarrabi, Hossein Pourghadamyari, Roghayeh Paydar, Roshanak Khojasteh, Somayeh Mousavi, Nadia Kia, Maral Amini, Majid Ghayour-Mobarhan, Gordon FernsGordon FernsWe studied the immune responses to heat shock protein (Hsp)-27 and pro-oxidant-antioxidant balance (PAB) values in patients with valvular heart disease, but free of angiographically evident coronary artery disease (CAD). Patients who were candidates for valvuloplasty surgery and 30 healthy matched controls were recruited. The anti-Hsp-27 antibody titers were 0.35 ± 0.04 absorbency units (AU) in the valvuloplasty group, being significantly higher than for the controls (0.11 ± 0.02 AU; P < .05). The PAB values were significantly higher in cases (134.67 ± 13.69 Hamidi-Koliakos(HK) unit) when compared with controls (49.78 ± 6.75 HK unit; P < .05). In cases, the ejection fraction was inversely correlated with anti-Hsp-27 antibody (P < .05) but was not significantly related to PAB values (P > .05). Based on the echocardiographic findings, the patients had no evident heart failure, but the high levels of anti-Hsp-27 and PAB values in patients with valvular heart disease may indicate that these variables can be used as markers of heart failure. However, a longitudinal study is required to confirm this hypothesis.
History
Publication status
- Published
Journal
AngiologyISSN
1940-1574Publisher
SAGE PublicationsExternal DOI
Issue
8Volume
63Page range
609-616Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-16Usage metrics
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