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Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation
journal contribution
posted on 2023-06-08, 13:47 authored by Fatemeh Tara, Margaret P Rayman, Hassan Boskabadi, Majid Ghayour-Mobarhan, Amirhossein Sahebkar, Daryoush H Alamdari, Behjat S Razavi, Shima Tavallaie, Mohsen Azimi-Nezhad, Mohammad T Shakeri, Mohammadreza Oladi, Omid Yazarlu, Shaida Ouladan, Maryam Teimoori Sangani, Fatemeh Rezagholizadeh Omran, Gordon FernsGordon FernsOBJECTIVE We assessed the impact of selenium, a trace element with antioxidant properties on a simple measure of oxidative stress in pregnant women. STUDY DESIGN A novel assay of prooxidant-antioxidant balance (PAB) was applied in a double-blind, placebo-controlled study of selenium supplementation in pregnancy. We measured the prooxidant burden and the antioxidant capacity simultaneously in one assay, thereby calculating a redox index. A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomized to receive 100 microg of selenium (n=83) or placebo (n=83) per day until delivery. PAB values and serum selenium concentrations were measured at baseline and at the end of study. RESULTS Pretreatment demographic data and biochemical indices including serum selenium concentrations did not differ significantly between the groups. The drop-out rates for the groups were 22/83 and 19/83 for the selenium and placebo groups, respectively. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration (P<0.001) but without significant change in mean PAB value. In contrast, mean serum selenium concentration remained unchanged and mean PAB values increased significantly (P<0.05 in the control group). CONCLUSION Our findings suggest that selenium supplementation may reduce oxidative stress associated with pregnancy
History
Publication status
- Published
Journal
Journal of Perinatal MedicineISSN
1619-3997External DOI
Issue
5Volume
38Page range
473-478Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-11-19Usage metrics
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