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Serum selenium and glutathione peroxidase concentrations in Iranian patients with angiography-defined coronary artery disease

journal contribution
posted on 2023-06-08, 13:48 authored by Seyyed Mohammad Reza Parizadeh, Mohsen Moohebati, Fahimeh Ghafoori, Majid Ghayour-Mobarhan, Seyyed Mohammad Reza Kazemi-Bajestani, Shima Tavallaie, Mohsen Azimi-Nezhad, Gordon FernsGordon Ferns
This study investigated the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) among Iranian patients. Three groups were compared: patients undergoing angiography with angiographically defined CAD, individuals with a normal angiogram, and apparently healthy controls with no evidence of overt CAD. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profiles, serum Se and GPx measurements, and angiographic assessment were carried out using standard protocols. Mean serum Se concentrations were not significantly different between patients with and without CAD and the control group. The mean value of serum GPx in the control group was significantly higher than in patients with or without CAD. Selenium status did not differentiate between patients with and without CAD, which may be related to the fact that angiography is not a very sensitive index of global atherosclerosis, and it is possible that patients who were CAD negative by angiogram still have significant disease. It may also be that Se is not a good marker of CAD

History

Publication status

  • Published

Journal

Angiology

ISSN

1940-1574

Publisher

SAGE Publications

Issue

2

Volume

60

Page range

186-191

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-11-19

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