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Gold amides as anticancer drugs: synthesis and activity studies
journal contribution
posted on 2023-06-08, 14:41 authored by Sonya Newcombe, Mariusz Bobin, Amruta Shrikhande, Chris Gallop, Yannick Pace, Helen Yong, Rebecca Gates, Shuvashri Chaudhuri, Mark Roe, Eva Hoffmann, Eddy ViseuxModular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.
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Publication status
- Published
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- Published version
Journal
Organic and Biomolecular ChemistryISSN
1477-0520Publisher
Royal Society of ChemistryExternal DOI
Issue
11Volume
19Page range
3255-3260Department affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2013-04-15First Open Access (FOA) Date
2013-04-15First Compliant Deposit (FCD) Date
2013-04-15Usage metrics
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