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Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM
journal contribution
posted on 2023-06-15, 14:44 authored by Jesús A Carballo, Rita S ChaBudding yeast Mec1, a homolog of mammalian ATR/ATM, is an essential chromosome-based signal transduction protein. Mec1 is a key checkpoint regulator and plays a critical role in the maintenance of genome stability. Mec1 is also required for meiosis; loss of Mec1 functions leads to a number of meiotic defects including reduction in recombination, loss of inter-homolog bias, loss of crossover control, and failure in meiotic progression. Here we review currently available data on meiotic defects associated with loss of Mec1 functions and discuss the possibility that Mec1 may participate as a fundamentally positive player in coordinating and promoting basic meiotic chromosomal processes during normal meiosis.
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Publication status
- Published
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- Published version
Journal
Chromosome ResearchISSN
0967-3849Publisher
Springer VerlagExternal DOI
Issue
5Volume
15Page range
539-550Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2014-07-11First Compliant Deposit (FCD) Date
2014-07-11Usage metrics
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