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Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups

journal contribution
posted on 2023-06-08, 18:34 authored by Jahangir Amin, Irina Chuckowree, Minghua Wang, Graham J Tizzard, Simon J Coles, John SpencerJohn Spencer
A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.

History

Publication status

  • Published

Journal

Organometallics

ISSN

0276-7333

Publisher

American Chemical Society

Issue

20

Volume

32

Page range

5818-5825

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-09-30

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