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Enhancement of percutaneous absorption of Finasteride by cosolvents, cosurfactant and surfactants

journal contribution
posted on 2023-06-08, 19:21 authored by Yousef Javadzadeh, Javad Shokri, Somayeh Hallaj-Nezhadi, Hamed Hamishehkar, Ali Nokhodchi
The enhancing effects of routinely used co-solvents, propylene glycol and 2-propanol, anionic and cationic surfactants and a co-surfactant with different concentrations were evaluated on the skin permeation of Finasteride. In vitro permeation experiments with rat skin revealed that the solvent mixture is a very important factor in the penetration of Finasteride through the skin. Unexpectedly, cationic and anionic surfactants in various concentrations did not show any enhancement effect on drug transdermal absorption but co-surfactant Transcutol P increased skin penetration of Finastride significantly. Transcutol P with 0.25% and 1% showed the best enhancement in the initial and final sampling time, respectively. Transcutol P in a concentration of 0.25% increased skin absorption of the drug nearly 3.6 times in the first 15min. The highest enhancement ratio (ER) was gained in the presence of 1% Transcutol P (ER = 5.98). In this study, among the different topical Finastride formulations, Transcutol P 1% in combination with water, propylene glycol and 2-propanol (30, 10, and 60) showed the highest enhancement ratio. © 2010 Informa Healthcare USA, Inc.

History

Publication status

  • Published

Journal

Pharmaceutical Development and Technology

ISSN

1083-7450

Publisher

Taylor & Francis

Issue

6

Volume

15

Page range

619-625

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-12-21

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