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Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

journal contribution
posted on 2023-06-08, 19:23 authored by Abolghasem Jouyban, Javad Shokri, Mohammad Jalali, Davoud Hassanzadeh, William E Acree Jr., Taravat Ghafourian, Ali Nokhodchi
Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. © 2009 American Chemical Society.

History

Publication status

  • Published

Journal

Journal of Chemical and Engineering Data

ISSN

0021-9568

Publisher

American Chemical Society

Issue

7

Volume

54

Page range

2142-2145

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2014-12-21

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