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HTS approaches to voltage-gated ion channel drug discovery

journal contribution
posted on 2023-06-08, 19:29 authored by Jane Denyer, Jennings Worley, Brian Cox, Gary Allenby, Martyn Banks
Voltage-gated ion channels are emerging as a target class of increasing importance to the pharmaceutical industry because of their relevance to a wide variety of diseases in the cardiovascular, CNS and metabolic areas. In the quest to identify novel lead molecules against these targets, drug discovery programmes are increasingly making use of HTS approaches. The authors describe the current technologies available for voltage-gated ion-channel screening, their application to HTS campaigns and the current limitations and emerging technologies within this area.

History

Publication status

  • Published

Journal

Drug Discovery Today

ISSN

1359-6446

Publisher

Elsevier

Issue

7

Volume

3

Page range

323-332

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-12

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    University of Sussex (Publications)

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