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A versatile procedure for the generation of nucleoside 5'-carboxylic acids using nucleoside oxidase
journal contribution
posted on 2023-06-08, 19:31 authored by Mahmoud Mahmoudian, Brian A M Rudd, Brian Cox, Chris S Drake, Richard M Hall, Paul Stead, Michael J Dawson, Malcolm Chandler, David G Livermore, Nicholas J Turner, Gareth JenkinsThe nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5'-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale.
History
Publication status
- Published
Journal
TetrahedronISSN
0040-4020Publisher
ElsevierExternal DOI
Issue
28Volume
54Page range
8171-8182Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-13Usage metrics
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