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For the benefit of others: reasons why women with breast cancer participate in RCTs

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journal contribution
posted on 2023-06-08, 20:21 authored by Valerie JenkinsValerie Jenkins, Lesley FallowfieldLesley Fallowfield
Introduction: Appreciation of the barriers and drivers affecting enrolment in randomised clinical trials (RCTs) is important for future trial design, communication and information provision. Method: As part of an intervention to facilitate UK multidisciplinary team communication about RCTs, women with breast cancer who discussed trials with doctors and/or research nurses completed questionnaires examining: - clarity of trial information and reasons for either accepting or declining trial entry. Results: 152 women with breast cancer completed the questionnaires; 113/152 (74%) consented to RCT enrolment. Patients’ satisfaction with communication about the trial information was very good, irrespective of participation decisions. Acceptors’ and decliners’ responses to 9/16 statements concerning decisions about trial participation differed significantly. ‘Wanting to help with doctor’s research’ influenced 100% acceptors compared to 57% of decliners (p<.001). Decliners were more likely to be ‘worried about randomisation’ (20% v 39%; p<.035) and to ‘want doctor to choose treatment rather than be randomised’ (31% v 53%; p<.031). Primary reason for trial acceptance was altruism; “I feel that others with my illness will benefit from the results of the trial”, 58/108 (54%). Conclusion: A majority of women accepted RCT entry citing altruistic motivations as the primary driver for participation. Trial design and setting (metastatic or adjuvant) had little impact on participation.

Funding

Supportive interventions in cancer.; G0004; CANCER RESEARCH UK; C54/A7374

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Breast Care

ISSN

1661-3805

Publisher

Karger

Issue

2

Volume

10

Department affiliated with

  • Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-03-19

First Open Access (FOA) Date

2015-03-19

First Compliant Deposit (FCD) Date

2015-03-19

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