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A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazole
journal contribution
posted on 2023-06-08, 20:44 authored by Lucas Lemaire, Natascha Leleu-Chavain, Aurélien Tourteau, Alaa Abdul-Sada, John SpencerJohn Spencer, Régis MilletStarting from a 5-amino-2-phenyloxazole-4-carbonitrile building block 3, obtained by reaction of benzoyl chloride (1) and aminomalononitrile p-toluenesulfonate (2), a large range of molecules were synthesized in one or two steps. A total of seven pyrimido[5,4-d]oxazoles 5(a–d)–8 and four pyrido[3,2-d]oxazoles 9–12 have been synthesized. Moreover, synthetic procedures have been adapted to overcome the instability of the oxazole ring.
History
Publication status
- Published
Journal
Tetrahedron LettersISSN
0040-4039Publisher
ElsevierExternal DOI
Issue
19Volume
56Page range
2448-2450Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-05-15Usage metrics
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