Waiting_impulsivity__the_influence_of_acute_methylphenidate_and_feedback.pdf (1.05 MB)
Waiting impulsivity: the influence of acute methylphenidate and feedback
journal contribution
posted on 2023-06-08, 22:06 authored by Neil Harrison, Valerie Voon, Ella Cooper, Jon Grant, Trevor W Robbins, Yee Chien Chang-Webb, Laurel S Morris, Arjun Sethi, Kwangyeol BaekBackground: The ability to wait and to weigh evidence is critical to behavioral regulation. These behaviors are known as waiting and reflection impulsivity. In Study 1, we examined the effects of methylphenidate, a dopamine and norepinephrine reuptake inhibitor, on waiting and reflection impulsivity in healthy young individuals. In study 2, we assessed the role of learning from feedback in disorders of addiction. Methods: We used the recently developed 4-Choice Serial Reaction Time task and the Beads task. Twenty-eight healthy volunteers were tested twice in a randomized, double-blind, placebo-controlled cross-over trial with 20mg methylphenidate. In the second study, we analyzed premature responses as a function of prior feedback in disorders of addiction. Results: Study 1: Methylphenidate was associated with greater waiting impulsivity to a cue predicting reward along with faster responding to target onset without a generalized effect on reaction time or attention. Methylphenidate influenced reflection impulsivity based on baseline impulsivity. Study 2: More premature responses occurred after premature responses in stimulant-dependent subjects. Conclusions: We show that methylphenidate has dissociable effects on waiting and reflection impulsivity. Chronic stimulant exposure impairs learning from prior premature responses, suggesting a failure to learn that premature responding is suboptimal. These findings provide a greater mechanistic understanding of waiting impulsivity.
History
Publication status
- Published
File Version
- Published version
Journal
International Journal of NeuropsychopharmacologyISSN
1461-1457Publisher
Oxford University PressExternal DOI
Issue
1Volume
19Page range
pyv074 1-10Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-08-13First Open Access (FOA) Date
2015-08-13First Compliant Deposit (FCD) Date
2015-08-13Usage metrics
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