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Fluorescence lifetime estimation method for incomplete decay
journal contribution
posted on 2023-06-08, 22:23 authored by Hongqi Yu, David Day-Uei LiA new incomplete decay signal model is proposed to describe the incomplete decay effects in a time- correlated single-photon counting (TCSPC) based fluorescence lifetime imaging (FLIM) system. Based on this model, we modified a MUltiple SIgnal Classification (MUSIC) algorithm to eliminate the incomplete decay effects. Monte Carlo simulations were carried out to demonstrate the performances of the proposed approach. Simulations show that the proposed method is insensitive to the laser pulse rate and has a larger lifetime dynamic range compared with previously reported approaches. As far as we know, this new method is the first non-fitting method that can resolve incomplete decay effects for multi-exponential decays.
History
Publication status
- Published
File Version
- Accepted version
Journal
Electronics LettersISSN
0013-5194Publisher
Institution of Engineering and TechnologyExternal DOI
Issue
21Volume
51Page range
1666-1668Department affiliated with
- Engineering and Design Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-04First Open Access (FOA) Date
2016-04-12First Compliant Deposit (FCD) Date
2015-09-04Usage metrics
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