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Mechanisms of regulation of mature miRNAs
journal contribution
posted on 2023-06-08, 23:56 authored by Benjamin P Towler, Chris JonesChris Jones, Sarah NewburySarah NewburyMicroRNAs (miRNAs) are short RNA molecules of around 22nt in length that play important roles in post-transcriptional control of gene expression. miRNAs normally function as negative regulators of mRNA expression by binding complementary sequences in the 3’ UTR of target mRNAs and causing translational repression and/or target degradation. Much research has been undertaken to enhance understanding of the biogenesis, function and targeting of miRNAs. However, until recently, the mechanisms underlying the regulation of the levels of mature miRNAs themselves have been largely overlooked. Although it has generally been assumed that miRNAs are stable molecules, recent evidence indicates that the stability of specific mature miRNAs can be regulated during key cellular and developmental processes in certain cell types. Here we discuss the current knowledge of the mechanisms by which mature miRNAs are regulated in the cell and the factors that contribute to the control of their stability.
Funding
Studentship-Towler; WC003-11; BSMS; WC003-11
Epigenetic regulation of gene expression by the exoribonuclease pacman; G0056; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/I021345/1
History
Publication status
- Published
File Version
- Published version
Journal
Biochemical Society TransactionsISSN
0300-5127Publisher
Portland PressExternal DOI
Issue
6Volume
43Page range
1208-1214Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-11First Compliant Deposit (FCD) Date
2016-01-11Usage metrics
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