File(s) under permanent embargo
MicroRNA-encoded behavior in Drosophila
journal contribution
posted on 2023-06-08, 23:59 authored by Joao Picao-Osorio, Jamie Johnston, Matthias Landgraf, Jimena BerniJimena Berni, Claudio AlonsoClaudio AlonsoThe relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored. We found that mutation of a single miRNA locus (miR-iab4/iab8) in Drosophila larvae affects the animal’s capacity to correct its orientation if turned upside down (self-righting). One of the miRNA targets involved in this behavior is the Hox gene Ultrabithorax, whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants, whereas thermogenetic manipulation of SRN activity results in changes in self-righting behavior. Our work thus reveals a miRNA-encoded behavior and suggests that other miRNAs might also be involved in behavioral control in Drosophila and other species.
Funding
The molecular regulation of Hox genes during animal development; G0952; WELLCOME TRUST; 098410/Z/12/Z
History
Publication status
- Published
File Version
- Published version
Journal
ScienceISSN
0036-8075Publisher
American Association for the Advancement of ScienceExternal DOI
Issue
6262Volume
350Page range
815-820Department affiliated with
- Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-15First Compliant Deposit (FCD) Date
2016-01-15Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC