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2013 - Mallo and Alonso_Development Hox Review.pdf (1.08 MB)

The regulation of Hox gene expression during animal development

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posted on 2023-06-09, 00:25 authored by Moisés Mallo, Claudio AlonsoClaudio Alonso
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns, the disruption of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene expression in model vertebrates and invertebrates and find that a diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation, all concur to control Hox gene outputs. We propose that this complex multi-tiered regulation might contribute to the robustness of Hox expression during development.

History

Publication status

  • Published

File Version

  • Published version

Journal

Development

ISSN

0950-1991

Publisher

Company of Biologists

Issue

19

Volume

140

Page range

3951-3963

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-03-02

First Open Access (FOA) Date

2016-03-02

First Compliant Deposit (FCD) Date

2016-03-02

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