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Stephens_et_al-2016-Genes,_Brain_and_Behavior.pdf (2.25 MB)

GABAA receptor subtype involvement in addictive behaviour

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journal contribution
posted on 2023-06-09, 02:41 authored by D N Stephens, Sarah KingSarah King, J J Lambert, D Belelli, Dora Duka
GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarise the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarise the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA Receptor Subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Genes, Brain and Behavior

ISSN

1601-1848

Publisher

Wiley

Issue

1

Volume

16

Page range

149-184

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-31

First Open Access (FOA) Date

2017-08-20

First Compliant Deposit (FCD) Date

2016-08-31

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