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Superantigen antagonist peptides

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journal contribution
posted on 2023-06-21, 06:01 authored by Martin LlewelynMartin Llewelyn, Jonathan Cohen
The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to be directed at blocking the three-way interaction between superantigen, T cell receptor and major histocompatibility class II molecule, which inititates an excessive and disordered inflammatory response. In this article, we review the first published data to address one such strategy in the context of other recognised and experimental treatments.

History

Publication status

  • Published

File Version

  • Published version

Journal

Critical Care

ISSN

1364-8535

Publisher

BioMed Central

Volume

5

Page range

53-55

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-10-03

First Open Access (FOA) Date

2016-10-03

First Compliant Deposit (FCD) Date

2016-10-03

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