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Neural substrates of motor and cognitive dysfunctions in SCA2 patients: a network based statistics analysis

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Version 2 2023-06-12, 08:40
Version 1 2023-06-09, 05:33
journal contribution
posted on 2023-06-12, 08:40 authored by G Olivito, Mara Cercignani, M Lupo, C Iacobacci, S Clausi, S Romano, M Masciullo, M Molinari, Marco Bozzali, M Leggio
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiatric symptoms. The cerebellum is known to modulate cortical activity and to contribute to distinct functional networks related to higher-level functions beyond motor control. It is therefore conceivable that one or more networks, rather than isolated regions, may be dysfunctional in cerebellar degenerative diseases and that an abnormal connectivity within specific cerebello-cortical regions might explain the widespread deficits typically observed in patients. In the present study, the network-based statistics (NBS) approach was used to assess differences in functional connectivity between specific cerebellar and erebral “nodes” in SCA2 patients. Altered inter-nodal connectivity was found between more posterior regions in the cerebellum and regions in the cerebral cortex clearly related to cognition and emotion. Furthermore, more anterior cerebellar lobules showed altered inter-nodal connectivity with motor and somatosensory cerebral regions. The present data suggest that in SCA2 a cerebellar dysfunction affects long-distance cerebral regions and that the clinical symptoms may be specifically related with connectivity changes between motor and non-motor cerebello-cortical nodes.

History

Publication status

  • Published

File Version

  • Published version

Journal

NeuroImage: Clinical

ISSN

2213-1582

Publisher

Elsevier

Volume

14

Page range

719-725

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-03-28

First Open Access (FOA) Date

2017-03-28

First Compliant Deposit (FCD) Date

2017-03-28

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