1-s2.0-S2213158217300694-main.pdf (354.34 kB)
Neural substrates of motor and cognitive dysfunctions in SCA2 patients: a network based statistics analysis
Version 2 2023-06-12, 08:40
Version 1 2023-06-09, 05:33
journal contribution
posted on 2023-06-12, 08:40 authored by G Olivito, Mara Cercignani, M Lupo, C Iacobacci, S Clausi, S Romano, M Masciullo, M Molinari, Marco Bozzali, M LeggioSpinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiatric symptoms. The cerebellum is known to modulate cortical activity and to contribute to distinct functional networks related to higher-level functions beyond motor control. It is therefore conceivable that one or more networks, rather than isolated regions, may be dysfunctional in cerebellar degenerative diseases and that an abnormal connectivity within specific cerebello-cortical regions might explain the widespread deficits typically observed in patients. In the present study, the network-based statistics (NBS) approach was used to assess differences in functional connectivity between specific cerebellar and erebral “nodes” in SCA2 patients. Altered inter-nodal connectivity was found between more posterior regions in the cerebellum and regions in the cerebral cortex clearly related to cognition and emotion. Furthermore, more anterior cerebellar lobules showed altered inter-nodal connectivity with motor and somatosensory cerebral regions. The present data suggest that in SCA2 a cerebellar dysfunction affects long-distance cerebral regions and that the clinical symptoms may be specifically related with connectivity changes between motor and non-motor cerebello-cortical nodes.
History
Publication status
- Published
File Version
- Published version
Journal
NeuroImage: ClinicalISSN
2213-1582Publisher
ElsevierExternal DOI
Volume
14Page range
719-725Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-03-28First Open Access (FOA) Date
2017-03-28First Compliant Deposit (FCD) Date
2017-03-28Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC