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High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow up study

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posted on 2023-06-09, 05:52 authored by Sayyed Saeid Khayyatzadeh, Seyed Jamal Mirmousavi, Mostafa Fazeli, Zahra Abasalti, Amir Avan, Ali Javandoost, Farzad Rahmani, Maryam Tayefi, Parichehr Hanachi, Gordon FernsGordon Ferns, Hamidreza Bahrami Taghanaki, Majid Ghayour-Mobarhan
Background: Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here we explored the effects of high-dose vitamin D supplementation on cardiometabolic risk factors. Methods: We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high dose vitamin D. All individuals took a capsule of 50000 IU vitamin D/ week for nine weeks. The study was completed by 940 participants. Results: the prevalence of vitamin D deficiency was 90% at baseline, reducing to16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum levels of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference, and serum fasting blood glucose, total- and low density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure, or serum high density lipoprotein-cholesterol and triglyceride. Conclusion: vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Annals of Clinical Biochemistry

ISSN

0004-5632

Publisher

SAGE Publications

Issue

2

Volume

55

Page range

227-235

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-04-24

First Open Access (FOA) Date

2017-04-24

First Compliant Deposit (FCD) Date

2017-04-21

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