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Novel salted anionic-cationic polymethacrylate polymer blends for sustained release of acidic and basic drugs

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posted on 2023-06-09, 06:11 authored by Wasfy M Obeidat, Duaa Qasim, Ali Nokhodchi, Ahmad Al-Jabery, AL-Sayed Sallam
Background: Since a unique matrix tablet formulation that independently controls the release of various drug types is in a great demand, the objective of this research was to develop a sustained release matrix tablet as a universal dosage form using a binary mixture of the salt forms of Eudragit polymers rather than their interpolyelectrolyte complexes. Methods: Tablets were prepared by wet granulation and compressed at different compression forces, depending on drug type. Dissolution tests were conducted using USP XXII rotating paddle apparatus at 50 rpm at 37°C in consecutive pH stages. Results: Tablets containing Ibuprofen (IB) as a model acidic drug and Metronidazole (MD) as a model basic drug showed controlled/sustained release behavior. For IB tablets containing 80% Ibuprofen and 5% (w/w) polymeric combination; the time for 50% of the drug release was about 24 hours compared to 8.5 hours for plain tablets containing 80% IB. In case of MD, the drug release extended to about 7 hours for tablets containing 80% MD and 5% (w/w) polymeric combination, compared to about 1 hour for plain tablets containing 80% MD. In terms of extending the release of medications, the dissolution profiles of the tablets containing polymeric salts forms were found to be statistically superior to tablets prepared by direct compression of the polymers in their powdered base forms, and superior to tablets containing the same polymers granulated using isopropyl alcohol. Conclusion: The findings indicated the significance of combining the polymers in their salt forms in controlling the release of various drug types from matrices.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Current Drug Delivery

ISSN

1567-2018

Publisher

Bentham Science Publishers

Issue

1

Volume

14

Page range

109-122

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-05-08

First Open Access (FOA) Date

2017-05-10

First Compliant Deposit (FCD) Date

2017-05-10

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