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Kinetically controlled coassembly of multichromophoric peptide hydrogelators and the impacts on energy transport

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posted on 2023-06-09, 07:28 authored by Herdeline Ann M Ardoña, Emily R Draper, Francesca Citossi, Matthew Wallace, Louise SerpellLouise Serpell, Dave J Adams, John D Tovar
We report a peptide-based multichromophoric hydrogelator system, wherein p-electron units with different inherent spectral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy gradients in aqueous environments. This is accomplished by mixing different p-conjugated peptides prior to initiating self-assembly through solution acidification. We can vary the kinetics of the assembly and the degree of self-sorting through the choice of the assembly trigger, which changes the kinetics of acidification. The hydrolysis of glucono-d-lactone (GdL) provides a slow pH drop that allows for stepwise triggering of peptide components into essentially self-sorted nanostructures based on subtle pKa differences, whereas HCl addition leads to a rapid formation of mixed components within a nanostructure. Using 1H NMR spectroscopy and fiber X-ray diffraction, we determine the conditions and peptide mixtures that favor self-sorting or intimate comixing. Photophysical investigations in the solution phase provide insight into the correlation of energy-transport processes occurring within the assemblies to the structural organization of the p-systems.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of the American Chemical Society

ISSN

0002-7863

Publisher

American Chemical Society

Issue

25

Volume

139

Page range

8685-8692

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Dementia Research Group Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-07-28

First Open Access (FOA) Date

2017-07-28

First Compliant Deposit (FCD) Date

2017-07-28

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