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Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning
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posted on 2023-06-09, 08:24 authored by Wajeeha AzizWajeeha Aziz, Wen Wang, Sebnem Kesaf, Alsayed Abdelhamid Mohamed, Yugo Fukazawa, Ryuichi ShigemotoLong-lasting memories are formed when the stimulus is temporally distributed (spacing effect). However, the synaptic mechanisms underlying this robust phenomenon and the precise time course of the synaptic modifications that occur during learning remain unclear. Here we examined the adaptation of horizontal optokinetic response in mice that underwent 1 h of massed and spaced training at varying intervals. Despite similar acquisition by all training protocols, 1 h of spacing produced the highest memory retention at 24 h, which lasted for 1 mo. The distinct kinetics of memory are strongly correlated with the reduction of floccular parallel fiber-Purkinje cell synapses but not with AMPA receptor (AMPAR) number and synapse size. After the spaced training, we observed 25%, 23%, and 12% reduction in AMPAR density, synapse size, and synapse number, respectively. Four hours after the spaced training, half of the synapses and Purkinje cell spines had been eliminated, whereas AMPAR density and synapse size were recovered in remaining synapses. Surprisingly, massed training also produced long-term memory and halving of synapses; however, this occurred slowly over days, and the memory lasted for only 1 wk. This distinct kinetics of structural plasticity may serve as a basis for unique temporal profiles in the formation and decay of memory with or without intervals.
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Publication status
- Published
Journal
Proceedings of the National Academy of SciencesISSN
1091-6490Publisher
National Academy of SciencesPublisher URL
External DOI
Issue
1Volume
111Article number
E194-202Department affiliated with
- BSMS Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-10-23Usage metrics
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