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Erratum: Interneuronal mechanism for Tinbergen's hierarchical model of behavioral choice

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posted on 2023-06-09, 12:21 authored by Zsolt Pirger, Michael CrossleyMichael Crossley, Zita Laszlo, Souvik Naskar, George KemenesGeorge Kemenes, Michael O'Shea, Paul Benjamin, Ildiko KemenesIldiko Kemenes
Recent studies of behavioral choice support the notion that the decision to carry out one behavior rather than another depends on the reconfiguration of shared interneuronal networks [1]. We investigated another decision-making strategy, derived from the classical ethological literature [2, 3], which proposes that behavioral choice depends on competition between autonomous networks. According to this model, behavioral choice depends on inhibitory interactions between incompatible hierarchically organized behaviors. We provide evidence for this by investigating the interneuronal mechanisms mediating behavioral choice between two autonomous circuits that underlie whole-body withdrawal [4, 5] and feeding [6] in the pond snail Lymnaea. Whole-body withdrawal is a defensive reflex that is initiated by tactile contact with predators. As predicted by the hierarchical model, tactile stimuli that evoke whole-body withdrawal responses also inhibit ongoing feeding in the presence of feeding stimuli. By recording neurons from the feeding and withdrawal networks, we found no direct synaptic connections between the interneuronal and motoneuronal elements that generate the two behaviors. Instead, we discovered that behavioral choice depends on the interaction between two unique types of interneurons with asymmetrical synaptic connectivity that allows withdrawal to override feeding. One type of interneuron, the Pleuro-Buccal (PlB), is an extrinsic modulatory neuron of the feeding network that completely inhibits feeding when excited by touch-induced monosynaptic input from the second type of interneuron, Pedal-Dorsal12 (PeD12). PeD12 plays a critical role in behavioral choice by providing a synaptic pathway joining the two behavioral networks that underlies the competitive dominance of whole-body withdrawal over feeding.

Funding

Decision Making in Neural Networks: Influence of Learning; G0189; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/H009906/1

Lapses in memory: opportunities for adaptive behaviour; G1199; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/K018515/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Current Biology

ISSN

0960-9822

Publisher

Elsevier

Issue

18

Volume

24

Page range

2018-2024

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Learning, Memory and Plasticity Group Publications

Notes

Original version: http://sro.sussex.ac.uk/49872/

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-03-05

First Open Access (FOA) Date

2018-03-05

First Compliant Deposit (FCD) Date

2018-03-01

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