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Does endocrine therapy for the treatment and prevention of breast cancer affect memory and cognition?
journal contribution
posted on 2023-06-07, 16:15 authored by Valerie JenkinsValerie Jenkins, Louise Atkins, Lesley FallowfieldLesley FallowfieldOestrogen receptors have been identified in several areas of the brain important in cognitive performance, including the prefrontal cortex (active during short-term working memory), the hippocampus and related cortical areas (learning and storage of information) and the amygdala (involved in the modulation of memory consolidation). There is much debate as to whether or not a reduction in oestrogen levels results in a corresponding decline in cognitive processing. Arguments for an effect are based on findings from laboratory and hormone replacement studies and the pharmacological actions of breast cancer drugs. However, there are few clinical data substantiating the claim that endocrine therapies used in the treatment and prevention of breast cancer could affect cognition. This paper examines the main evidence associated with this claim and discusses the importance of examining such issues within randomised trials.
History
Publication status
- Published
Journal
European Journal of CancerISSN
0959-8049Publisher
ElsevierExternal DOI
Issue
9Volume
43Page range
1342-1347Department affiliated with
- Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications
Full text available
- No
Peer reviewed?
- Yes