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Mathematical model of immune response to hepatitis B

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posted on 2023-06-09, 12:50 authored by F Fatehi Chenar, Yuliya KyrychkoYuliya Kyrychko, Konstantin BlyussKonstantin Blyuss
A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady states is performed to identify parameter regions where the model exhibits clearance of infection, maintenance of a chronic infection, or periodic oscillations. Effects of nucleoside analogues and interferon treatments are analysed, and the critical drug efficiency is determined.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Theoretical Biology

ISSN

0022-5193

Publisher

Elsevier

Volume

447

Page range

98-110

Department affiliated with

  • Mathematics Publications

Research groups affiliated with

  • Mathematics Applied to Biology Research Group Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-04-11

First Open Access (FOA) Date

2019-03-21

First Compliant Deposit (FCD) Date

2018-04-11

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