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A central control circuit for encoding perceived food value

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Version 2 2023-06-12, 07:27
Version 1 2023-06-09, 15:29
journal contribution
posted on 2023-06-12, 07:27 authored by Michael CrossleyMichael Crossley, Kevin StarasKevin Staras, George KemenesGeorge Kemenes
Hunger state can substantially alter the perceived value of a stimulus, even to the extent that the same sensory cue can trigger antagonistic behaviors. How the nervous system uses these graded perceptual shifts to select between opposed motor patterns remains enigmatic. Here, we challenged food-deprived and satiated Lymnaea to choose between two mutually exclusive behaviors, ingestion or egestion, produced by the same feeding central pattern generator. Decoding the underlying neural circuit reveals that the activity of central dopaminergic interneurons defines hunger state and drives network reconfiguration, biasing satiated animals toward the rejection of stimuli deemed palatable by food-deprived ones. By blocking the action of these neurons, satiated animals can be reconfigured to exhibit a hungry animal phenotype. This centralized mechanism occurs in the complete absence of sensory retuning and generalizes across different sensory modalities, allowing food-deprived animals to increase their perception of food value in a stimulus-independent manner to maximize potential calorific intake.

Funding

Ultrastructure-function properties of recycling vesicle pools in native central synapses; G1150; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/K019015/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Science Advances

ISSN

2375-2548

Publisher

American Association for the Advancement of Science

Issue

11

Volume

4

Page range

1-11

Department affiliated with

  • Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-10-12

First Open Access (FOA) Date

2018-11-22

First Compliant Deposit (FCD) Date

2018-10-11

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