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Locomotor sensitization to cocaine is associated with increased Fos expression in the accumbens, but not in the caudate

journal contribution
posted on 2023-06-07, 18:35 authored by Hans CrombagHans Crombag, Jakub P Jedynak, Kristina Redmond, Terry E Robinson, Bruce T Hope
Behavioral sensitization following repeated intermittent cocaine administrations is thought to involve alterations in cocaine regulation of neural activity within the accumbens and caudate brain regions. Although Fos immunohistochemistry and c-fos in situ hybridization have frequently been used to assess changes in cocaine-induced neural activity following prior cocaine exposure, these techniques have rarely been used to examine neural activity in the accumbens of behaviorally sensitized animals. In the present experiment, we compared the ability of increasing doses of cocaine to induce Fos in the accumbens and caudate of rats following a treatment procedure (7 once daily injections of 15 mg/kg of cocaine or the saline vehicle) shown to produce robust and persistent (1 week) locomotor sensitization. In sensitized animals, there was a leftward shift in the dose-response curve for cocaine induction of Fos in the accumbens, but not in the caudate. These results provide the first parametric evidence for sensitization of cocaine-induced Fos expression in the accumbens.

History

Publication status

  • Published

Journal

Behavioural Brain Research

ISSN

0166-4328

Publisher

Elsevier

Issue

2

Volume

136

Page range

455-462

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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