Lack of involvement of alpha-synuclein in unconditioned anxiety in mice

Peña-Oliver, Yolanda, Buchman, Vladimir L and Stephens, David N (2010) Lack of involvement of alpha-synuclein in unconditioned anxiety in mice. Behavioural Brain Research, 209 (2). pp. 234-240. ISSN 0166-4328

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Abstract

Alpha-synuclein is implicated in the pathology of Parkinson disease (PD) and is involved in synaptic function, particularly in presynaptic events in dopamine (DA) synapses. Recently, a role for alpha-synuclein in reward and addiction, especially in alcoholism, has been reported. Since PD and alcohol dependence present a strong comorbidity with anxiety disorders, a role for alpha-synuclein in anxiety has been proposed. The aim of the present investigation was to study the involvement of alpha-synuclein in anxiety by testing alpha-synuclein knock out and wild type mice in three different emotionality tests: the open field, the elevated plus maze and the light¿dark box. Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Depositing User: Yolanda Pena-Oliver
Date Deposited: 06 Feb 2012 15:51
Last Modified: 19 Mar 2012 12:33
URI: http://srodev.sussex.ac.uk/id/eprint/14775
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