TDP1-dependent DNA single-strand break repair and neurodegeneration

El-Khamisy, Sherif F and Caldecott, Keith W (2006) TDP1-dependent DNA single-strand break repair and neurodegeneration. Mutagenesis, 21 (4). pp. 219-224. ISSN 0267-8357

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DNA single-strand breaks (SSBs) are the commonest DNA lesions that arise spontaneously in living cells. Cells employ efficient processes for the rapid repair of these breaks and defects in these processes appear to preferentially impact on the nervous system, causing human ataxia. Spinocerebellar ataxia with axonal neuropathy (SCAN1) is a human disease that is associated with a defect in repairing certain types of SSBs. Although it is a rare neurodegenerative disease, understanding the molecular basis of SCAN1 will lead to better understanding of the mechanisms that underpin not only neurodegeneration but also cancer.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Sherif El-Khamisy
Date Deposited: 06 Feb 2012 18:20
Last Modified: 29 Mar 2012 09:33
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