The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides

Sanderson, John M, Singh, P, Fishwick, Colin W G and Findlay, John B C (2000) The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides. Journal of the Chemical Society, Perkin Transactions 1, 19. 3227 - 3231. ISSN 0300-922X

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Abstract

The synthesis and reactivity of fully protected thioamide analogues of asparagine and glutamine are described. A key feature of the synthetic strategies employed was the ability to perform selective thiations on multiple carbonyl-containing substrates. Also described are the preparations of thioamide derivatives of phenylalanine. The utility of these amino acid derivatives for solid-phase peptide synthesis is discussed.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 18:26
Last Modified: 14 Sep 2012 10:47
URI: http://srodev.sussex.ac.uk/id/eprint/16384
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