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Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

journal contribution
posted on 2023-06-07, 20:31 authored by Dmitriy Alexeev, Paul N Barlow, Stella M Bury, Jean-Damien Charrier, Alan Cooper, David Hadfield, Craig Jamieson, Sharon M Kelly, Robert Layfield, R John Mayer, Helen McSparron, Nicholas C Price, Robert Ramage, Lindsay Sawyer, Bernard A Starkmann, Dusan Uhrin, Jill Wilken, Douglas W Young
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History

Publication status

  • Published

Journal

ChemBioChem

ISSN

1439-4227

Publisher

Wiley

Issue

9

Volume

4

Page range

894-896

Pages

3.0

Department affiliated with

  • Chemistry Publications

Notes

DWY is corresponding author and directed the synthetic work. The work reports the first ubiquitin variants in which selected leucine residues in the hydrophobic core have been replaced by (2S,4S)-5-fluoroleucine residues. Protein X-ray crystallographic, 19F-NMR and biophysical methods were used to show that protein folding was unafected.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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