SUMO modification of proteins other than transcription factors

Watts, Felicity (2004) SUMO modification of proteins other than transcription factors. Seminars in Cell & Developmental Biology, 15 (2). pp. 211-220. ISSN 10849521

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A wide range of eukaryotic proteins has been shown to be sumoylated. Most, but not all of these proteins are nuclear. In all cases documented so far, sumoylation has been shown to occur on lysine residues. In general these are located within the consensus sequence ¿KxE, although there are some exceptions to this. The role of sumoylation has been investigated for a number of identified targets. Unlike the situation with ubiquitination, sumoylation does not appear to target proteins for proteasome-mediated degradation. In contrast, the effect of SUMO modification appears to depend on the target protein and includes roles in altering protein activity, protein-protein interactions or protein localisation.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Felicity Watts
Date Deposited: 06 Feb 2012 19:09
Last Modified: 23 Jul 2012 11:17
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