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Spatial navigation and causal analysis in a brain-based device having detailed cortical-hippocampal interactions
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posted on 2023-06-07, 22:25 authored by Jeffrey L Krichmar, Anil SethAnil Seth, Douglas A Nitz, Jason G Fleischer, Gerald M EdelmanWe describe Darwin X, a physical device that interacts with a real environment, whose behavior is guided by a simulated nervous system incorporating aspects of the detailed anatomy and physiology of the hippocampus and its surrounding regions. This brain-based device integrates cues from its environment and solves a spatial memory task. The responses of simulated neuronal units in the hippocampal areas during its exploratory behavior are comparable to place cells in the rodent hippocampus. These place units emerged by integrating visual and self-movement cues during exploration with only minimal assumptions about the environmental inputs into the model. To identify different functional hippocampal pathways and their influence on behavior, we employed a time series analysis that distinguishes causal interactions within and between simulated hippocampal and neocortical regions while the device is engaged in a spatial memory task. Our analysis identified different functional pathways within the neural simulation and prompts novel predictions about the influence of the perforant path, the tri-synaptic loop and hippocampal-cortical interactions on place cell activity and behavior during navigation. Moreover, this causal time series analysis may be useful in analyzing networks in general, neural or otherwise.
History
Publication status
- Published
Journal
NeuroinformaticsISSN
1539-2791Publisher
HUMANA PRESS INCExternal DOI
Issue
3Volume
3Page range
197-221Pages
25.0Department affiliated with
- Informatics Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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