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An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the `Legs at odd angles¿ (Loa) mutation

journal contribution
posted on 2023-06-07, 22:30 authored by Abi S Witherden, Majid HafezparastMajid Hafezparast, Sharon J Nicholson, Azlina Ahmad-Annuar, Nessan Bermingham, Demet Arac, Joanna Rankin, Marjan Iravani, Simon Ball, Jo Peters, Joanne E Martin, Derek Huntley, Holger Hummerich, Marek Sergot, Elizabeth M C Fisher
A variety of loci with interesting patterns of regulation such as imprinted expression, and critical functions such as involvement in tumour necrosis factor pathways, map to a distal portion of mouse chromosome 12. This region also contains disease related loci including the 'Legs at odd angles' mutation (Loa) that we are pursuing in a positional cloning project. To further define the region and prepare for comparative sequencing projects, we have produced genetic, radiation hybrid, physical and transcript maps of the region, with probes providing anchors between the maps. We show a summary of 95 markers and 91 genomic clones that has enabled us to identify 18 transcripts including new genes and candidates for Loa which will help in future studies of gene context and regulation.

History

Publication status

  • Published

Journal

Gene

ISSN

0378-1119

Issue

1-2

Volume

283

Page range

71-82

Pages

12.0

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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