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The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs

journal contribution
posted on 2023-06-07, 22:39 authored by Ernesto Sánchez-Herrero, Juan Pablo Couso, Javier Capdevila, Isabel Guerrero
The genes decapentaplegic (dpp) and wingless (wg), which encode secreted factors of the TGF-ß and Wnt families, respectively, are required for the proper development of the imaginai discs. The expression of these genes must be finely regulated since their ectopic expression induces overgrowth and pattern alterations in wings and legs. Genes like patched (ptc) and costal-2 (cos-2), and the gene encoding the catalytic subunit of the protein kinase A gene (pkA) are required to restrict dpp and wg expression in their proper positions. We show here that some mutations in the cubitus interrupts (ci) gene also show ectopic dpp expression in the wing disc. We have also analyzed the functional hierarchy between these genes and the gene fused (FU), in the activation of dpp by the hedgehog (hh) signal. fu is required to transmit the hh signal in imaginai discs, since fu mutations rescue the phenotype due to the ectopic hh expression or to the lack of ptc activity. fu is also required for the activation of engrailed (en) caused when hh is ectopically activated in the wing disc. By contrast, fu mutations do not rescue the phenotypic consequences of the abnormal ci, cos-2 or pkA activity. Although fu, cos-2 and ci probably form part of the same pathway that controls dpp expression, pkA probably controls dpp transcription by a different pathway.

History

Publication status

  • Published

Journal

Mechanisms of Development

ISSN

09254773

Publisher

Mechanisms of Development

Issue

2

Volume

55

Page range

159-170

ISBN

0265-9247

Department affiliated with

  • Clinical and Experimental Medicine Publications

Notes

Describes the roles of the fused kinase in hedhehog signalling

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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