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The role of Schizosaccharomyces pombe SUMO ligases in genome stability

journal contribution
posted on 2023-06-07, 14:54 authored by Felicity Watts, Andrew Skilton, J C Ho, Lara Katrina Boyd, M A Trickey, Lisa Gardner, Francois-Xavier Ogi
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins.

History

Publication status

  • Published

Journal

Biochemical Society Transactions

ISSN

0300-5127

Publisher

Portland Press

Issue

6

Volume

35

Page range

1379-1384

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

GDSC260

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2008-10-28

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