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Galactose-phosphonates as mimetics of the sialyltransfer by trypanosomal sialidases

journal contribution
posted on 2023-06-07, 23:03 authored by Heike Busse, Mitsuru Hakoda, Matthew Stanley, Hansjorg Streicher
In an attempt to find competitive inhibitors of the trans- sialidase of the pathogen Trypanosoma cruzi, we have synthesized conjugates of carbocyclic sialylmimetics ( e. g., cyclohexenephosphonates) and galactose derivatives. A trans- sialidase inhibition assay revealed an interesting preference for ethylidene- spacered conjugates involving the 3- position of the sugar.

History

Publication status

  • Published

Journal

Journal of Carbohydrate Chemistry

ISSN

0732-8303

Issue

3

Volume

26

Page range

159-194

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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