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Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists

journal contribution
posted on 2023-06-07, 23:08 authored by Simon E Ward, Peter J Eddershaw, Claire M Scott, Laurie J Gordon, Peter J Lovell, Susan H Moore, Paul W Smith, Kathryn R Starr, Kevin M Thewlis, Jeannette M Watson
5-HT1 receptor antagonists have been discovered with good selectivity over the 5-HT transporter. This is the first report of highly potent, selective ligands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of molecules for further understanding the roles of the 5-HT1 receptor subtypes and providing new approaches,for the treatment of depression.

History

Publication status

  • Published

Journal

Journal of Medicinal Chemistry

ISSN

0022-2623

Publisher

Elsevier

Issue

10

Volume

51

Page range

2887-2890

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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