XPD structure reveals its secrets

Lehmann, Alan R. (2008) XPD structure reveals its secrets. DNA Repair, 7 (11). pp. 1912-1915. ISSN 1568-7864

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The XPD protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel "Arch" domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene.

Item Type: Article
Additional Information: On Endnotes Ref: GDSC262
Keywords: Helicase; TFIIH; Trichothiodystrophy; Xeroderma pigmentosum
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics
R Medicine > R Medicine (General)
Depositing User: Gee Wheatley
Date Deposited: 23 Feb 2009
Last Modified: 30 Nov 2012 16:53
URI: http://srodev.sussex.ac.uk/id/eprint/2110
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