Problems with parsimony in sequences of biased base composition

Eyre-Walker, Adam (1998) Problems with parsimony in sequences of biased base composition. Journal of Molecular Evolution, 47 (6). pp. 686-690. ISSN 0022-2844

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Parsimony is commonly used to infer the direction of substitution and mutation. However, it is known that parsimony is biased when the base composition of the DNA sequence is skewed. Here I quantify this effect for several simple cases. The analysis demonstrates that parsimony can be misleading even when levels of sequence divergence are as low as 10%; parsimony incorrectly infers an excess of common to rare changes. Caution must therefore be excercised in the use of parsimony.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 19:39
Last Modified: 18 Jun 2012 14:02
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