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How Bacillus thuringiensis has evolved specific toxins to colonize the insect world
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posted on 2023-06-07, 23:47 authored by Ruud A de Maagd, Alejandra Bravo, Neil CrickmoreNeil CrickmoreBacillus thuringiensis is a bacterium of great agronomic and scientific interest. Together the subspecies of this bacterium colonize and kill a large variety of host insects and even nematodes, but each strain does so with a high degree of specificity. This is mainly determined by the arsenal of crystal proteins that the bacterium produces during sporulation. Here we describe the properties of these toxin proteins and the current knowledge of the basis for their specificity. Assessment of phylogenetic relationships of the three domains of the active toxin and experimental results indicate how sequence divergence in combination with domain swapping by homologous recombination might have caused this extensive range of specificities.
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Publication status
- Published
Journal
Trends in GeneticsISSN
0168-9525External DOI
Issue
4Volume
17Page range
193-199Pages
7.0Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2012-02-06Usage metrics
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